Epigenomic characterization of Clostridioides difficile finds a conserved DNA methyltransferase that mediates sporulation and pathogenesis

Clostridioides difficile is a leading cause of health care-associated infections. Although significant progress has been made in the understanding of its genome, the epigenome of C. difficile and its functional impact has not been systematically explored. Here, we performed a comprehensive DNA methy...

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Publicado en:Nat Microbiol
Main Authors: Oliveira, Pedro H., Ribis, John W., Garrett, Elizabeth M., Trzilova, Dominika, Kim, Alex, Sekulovic, Ognjen, Mead, Edward A., Pak, Theodore, Zhu, Shijia, Deikus, Gintaras, Touchon, Marie, Lewis-Sandari, Martha, Beckford, Colleen, Zeitouni, Nathalie E., Altman, Deena R., Webster, Elizabeth, Oussenko, Irina, Bunyavanich, Supinda, Aggarwal, Aneel K., Bashir, Ali, Patel, Gopi, Wallach, Frances, Hamula, Camille, Huprikar, Shirish, Schadt, Eric E., Sebra, Robert, van Bakel, Harm, Kasarskis, Andrew, Tamayo, Rita, Shen, Aimee, Fang, Gang
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6925328/
https://ncbi.nlm.nih.gov/pubmed/31768029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41564-019-0613-4
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