Definition of functionally and structurally distinct repressive states in the nuclear receptor PPARγ

The repressive states of nuclear receptors (i.e., apo or bound to antagonists or inverse agonists) are poorly defined, despite the fact that nuclear receptors are a major drug target. Most ligand bound structures of nuclear receptors, including peroxisome proliferator-activated receptor γ (PPARγ), a...

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Udgivet i:Nat Commun
Main Authors: Heidari, Zahra, Chrisman, Ian M., Nemetchek, Michelle D., Novick, Scott J., Blayo, Anne-Laure, Patton, Trey, Mendes, Desiree E., Diaz, Philippe, Kamenecka, Theodore M., Griffin, Patrick R., Hughes, Travis S.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6925260/
https://ncbi.nlm.nih.gov/pubmed/31862968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13768-0
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