Defining a conformational ensemble that directs activation of PPARγ

The nuclear receptor ligand-binding domain (LBD) is a highly dynamic entity. Crystal structures have defined multiple low-energy LBD structural conformations of the activation function-2 (AF-2) co-regulator-binding surface, yet it remains unclear how ligand binding influences the number and populati...

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Publicado en:Nat Commun
Autores principales: Chrisman, Ian M., Nemetchek, Michelle D., de Vera, Ian Mitchelle S., Shang, Jinsai, Heidari, Zahra, Long, Yanan, Reyes-Caballero, Hermes, Galindo-Murillo, Rodrigo, Cheatham, Thomas E., Blayo, Anne-Laure, Shin, Youseung, Fuhrmann, Jakob, Griffin, Patrick R., Kamenecka, Theodore M., Kojetin, Douglas J., Hughes, Travis S.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5935666/
https://ncbi.nlm.nih.gov/pubmed/29728618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04176-x
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