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Definition of functionally and structurally distinct repressive states in the nuclear receptor PPARγ
The repressive states of nuclear receptors (i.e., apo or bound to antagonists or inverse agonists) are poorly defined, despite the fact that nuclear receptors are a major drug target. Most ligand bound structures of nuclear receptors, including peroxisome proliferator-activated receptor γ (PPARγ), a...
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| Izdano u: | Nat Commun |
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| Glavni autori: | , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group UK
2019
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6925260/ https://ncbi.nlm.nih.gov/pubmed/31862968 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13768-0 |
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