Differential effects of various genetic mouse models of the mechanistic target of rapamycin complex I inhibition on heart failure

Inhibition of mammalian target of rapamycin complex I (mTORC1) by rapamycin improves cardiac function in both aging and heart failure. While the protective mechanisms are not fully understood in mammals, they are presumably mediated through metabolic regulation and suppression of protein translation...

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Publicado en:GeroScience
Main Authors: Dai, Dao-Fu, Liu, Yonggang, Basisty, Nathan, Karunadharma, Pabalu, Dastidar, Somasish G., Chiao, Ying Ann, Chen, Tony, Beyer, Richard P., Chin, Michael T., Maccoss, Michael, La Spada, Albert R., Rabinovitch, Peter S.
Formato: Artigo
Idioma:Inglês
Publicado: Springer International Publishing 2019
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6925086/
https://ncbi.nlm.nih.gov/pubmed/31650481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11357-019-00119-6
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