Altered proteome turnover and remodeling by short-term caloric restriction or rapamycin rejuvenate the aging heart

Chronic caloric restriction (CR) and rapamycin inhibit the mechanistic target of rapamycin (mTOR) signaling, thereby regulating metabolism and suppressing protein synthesis. Caloric restriction or rapamycin extends murine lifespan and ameliorates many aging-associated disorders; however, the benefic...

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Detalhes bibliográficos
Main Authors: Dai, Dao-Fu, Karunadharma, Pabalu P, Chiao, Ying A, Basisty, Nathan, Crispin, David, Hsieh, Edward J, Chen, Tony, Gu, Haiwei, Djukovic, Danijel, Raftery, Daniel, Beyer, Richard P, MacCoss, Michael J, Rabinovitch, Peter S
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4040127/
https://ncbi.nlm.nih.gov/pubmed/24612461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12203
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