Rapamycin transiently induces mitochondrial remodeling to reprogram energy metabolism in old hearts

Rapamycin, an inhibitor of mTOR signaling, has been shown to reverse diastolic dysfunction in old mice in 10 weeks, highlighting its therapeutic potential for a poorly treatable condition. However, the mechanisms and temporal regulation of its cardiac benefits remain unclear. We show that improved d...

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Detalhes bibliográficos
Publicado no:Aging (Albany NY)
Main Authors: Chiao, Ying Ann, Kolwicz, Stephen C., Basisty, Nathan, Gagnidze, Arni, Zhang, Julia, Gu, Haiwei, Djukovic, Danijel, Beyer, Richard P., Raftery, Daniel, MacCoss, Michael, Tian, Rong, Rabinovitch, Peter S.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4789585/
https://ncbi.nlm.nih.gov/pubmed/26872208
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