Mitochondrial‐targeted catalase is good for the old mouse proteome, but not for the young: ‘reverse’ antagonistic pleiotropy?

Reactive oxygen species (ROS) are highly reactive oxygen‐containing molecules associated with aging and a broad spectrum of pathologies. We have previously shown that transgenic expression of the antioxidant enzyme catalase targeted to the mitochondria (mCAT) in mice reduces ROS, attenuates age‐rela...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Basisty, Nathan, Dai, Dao‐Fu, Gagnidze, Arni, Gitari, Lemuel, Fredrickson, Jeanne, Maina, Yvonne, Beyer, Richard P., Emond, Mary J., Hsieh, Edward J., MacCoss, Michael J., Martin, George M., Rabinovitch, Peter S.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933659/
https://ncbi.nlm.nih.gov/pubmed/27061426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12472
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