Rapamycin persistently improves cardiac function in aged, male and female mice, even following cessation of treatment

Even in healthy aging, cardiac morbidity and mortality increase with age in both mice and humans. These effects include a decline in diastolic function, left ventricular hypertrophy, metabolic substrate shifts, and alterations in the cardiac proteome. Previous work from our laboratory indicated that...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Quarles, Ellen, Basisty, Nathan, Chiao, Ying Ann, Merrihew, Gennifer, Gu, Haiwei, Sweetwyne, Mariya T., Fredrickson, Jeanne, Nguyen, Ngoc‐Han, Razumova, Maria, Kooiker, Kristina, Moussavi‐Harami, Farid, Regnier, Michael, Quarles, Christopher, MacCoss, Michael, Rabinovitch, Peter S.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6996961/
https://ncbi.nlm.nih.gov/pubmed/31823466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13086
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