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Rapamycin persistently improves cardiac function in aged, male and female mice, even following cessation of treatment

Even in healthy aging, cardiac morbidity and mortality increase with age in both mice and humans. These effects include a decline in diastolic function, left ventricular hypertrophy, metabolic substrate shifts, and alterations in the cardiac proteome. Previous work from our laboratory indicated that...

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書目詳細資料
發表在:Aging Cell
Main Authors: Quarles, Ellen, Basisty, Nathan, Chiao, Ying Ann, Merrihew, Gennifer, Gu, Haiwei, Sweetwyne, Mariya T., Fredrickson, Jeanne, Nguyen, Ngoc‐Han, Razumova, Maria, Kooiker, Kristina, Moussavi‐Harami, Farid, Regnier, Michael, Quarles, Christopher, MacCoss, Michael, Rabinovitch, Peter S.
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2019
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6996961/
https://ncbi.nlm.nih.gov/pubmed/31823466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13086
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