Subacute calorie restriction and rapamycin discordantly alter mouse liver proteome homeostasis and reverse aging effects

Calorie restriction (CR) and rapamycin (RP) extend lifespan and improve health across model organisms. Both treatments inhibit mammalian target of rapamycin (mTOR) signaling, a conserved longevity pathway and a key regulator of protein homeostasis, yet their effects on proteome homeostasis are relat...

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Vydáno v:Aging Cell
Hlavní autoři: Karunadharma, Pabalu P, Basisty, Nathan, Dai, Dao-Fu, Chiao, Ying A, Quarles, Ellen K, Hsieh, Edward J, Crispin, David, Bielas, Jason H, Ericson, Nolan G, Beyer, Richard P, MacKay, Vivian L, MacCoss, Michael J, Rabinovitch, Peter S
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley & Sons, Ltd 2015
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4531069/
https://ncbi.nlm.nih.gov/pubmed/25807975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12317
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