Respiratory chain protein turnover rates in mice are highly heterogeneous but strikingly conserved across tissues, ages, and treatments

The mitochondrial respiratory chain (RC) produces most of the cellular ATP and requires strict quality-control mechanisms. To examine RC subunit proteostasis in vivo, we measured RC protein half-lives (HLs) in mice by liquid chromatography-tandem mass spectrometry with metabolic [(2)H(3)]-leucine he...

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Vydáno v:FASEB J
Hlavní autoři: Karunadharma, Pabalu P., Basisty, Nathan, Chiao, Ying Ann, Dai, Dao-Fu, Drake, Rachel, Levy, Nick, Koh, William J., Emond, Mary J., Kruse, Shane, Marcinek, David, Maccoss, Michael J., Rabinovitch, Peter S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Federation of American Societies for Experimental Biology 2015
Témata:
Research Communication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4511201/
https://ncbi.nlm.nih.gov/pubmed/25977255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.15-272666
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