Bi-allelic Homology-Directed Repair with Helper-Dependent Adenoviruses

We describe a strategy to achieve footprintless bi-allelic homology-directed repair (HDR) using helper-dependent adenoviruses (HDAds). This approach utilizes two HDAds to deliver the donor DNA. These two HDAds are identical except for their selectable marker. One expresses the puromycin N-acetyltran...

Full description

Saved in:
Bibliographic Details
Published in:Mol Ther Methods Clin Dev
Main Authors: Palmer, Donna J., Turner, Dustin L., Ng, Philip
Format: Artigo
Language:Inglês
Published: American Society of Gene & Cell Therapy 2019
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6923503/
https://ncbi.nlm.nih.gov/pubmed/31890728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2019.10.003
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items