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Divalent Cations and Lipid Composition Modulate Membrane Insertion and Cancer-Targeting Action of pHLIP

The pH-Low Insertion Peptide (pHLIP) has emerged as an important tool for targeting cancer cells; it has been assumed that its targeting mechanism depends solely on the mild acidic environment surrounding tumors. Here, we examine the role of Ca(2+) and Mg(2+) on pHLIP’s insertion, cellular targeting...

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Foilsithe in:J Mol Biol
Main Authors: Vasquez-Montes, Victor, Gerhart, Janessa, Thévenin, Damien, Ladokhin, Alexey S.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2019
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6920566/
https://ncbi.nlm.nih.gov/pubmed/31689432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2019.10.016
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