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Divalent Cations and Lipid Composition Modulate Membrane Insertion and Cancer-Targeting Action of pHLIP
The pH-Low Insertion Peptide (pHLIP) has emerged as an important tool for targeting cancer cells; it has been assumed that its targeting mechanism depends solely on the mild acidic environment surrounding tumors. Here, we examine the role of Ca(2+) and Mg(2+) on pHLIP’s insertion, cellular targeting...
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| Опубликовано в: : | J Mol Biol |
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| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2019
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6920566/ https://ncbi.nlm.nih.gov/pubmed/31689432 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2019.10.016 |
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