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Transcriptional Silencing of MCL-1 Through Cyclin-Dependent Kinase Inhibition in Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is the most common adult acute leukemia. Survival remains poor, despite decades of scientific advances. Cytotoxic induction chemotherapy regimens are standard-of-care for most patients. Many investigations have highlighted the genomic heterogeneity of AML, and several ne...

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Detalles Bibliográficos
Publicado en:Front Oncol
Main Authors: Tibes, Raoul, Bogenberger, James M.
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2019
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6920180/
https://ncbi.nlm.nih.gov/pubmed/31921615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.01205
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