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Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2

The Polycomb group (PcG) protein, enhancer of zeste homologue 2 (EZH2), has an essential role in promoting histone H3 lysine 27 trimethylation (H3K27me3) and epigenetic gene silencing(1–4). This function of EZH2 is important for cell proliferation and inhibition of cell differentiation, and is impli...

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Detalhes bibliográficos
Main Authors: Chen, Shuai, Bohrer, Laura R., Rai, Aswathy N., Pan, Yunqian, Gan, Lu, Zhou, Xianzheng, Bagchi, Anindya, Simon, Jeffrey A., Huang, Haojie
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3292434/
https://ncbi.nlm.nih.gov/pubmed/20935635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2116
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