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Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2
The Polycomb group (PcG) protein, enhancer of zeste homologue 2 (EZH2), has an essential role in promoting histone H3 lysine 27 trimethylation (H3K27me3) and epigenetic gene silencing(1–4). This function of EZH2 is important for cell proliferation and inhibition of cell differentiation, and is impli...
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| Autors principals: | , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3292434/ https://ncbi.nlm.nih.gov/pubmed/20935635 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2116 |
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