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Transcriptional Silencing of MCL-1 Through Cyclin-Dependent Kinase Inhibition in Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is the most common adult acute leukemia. Survival remains poor, despite decades of scientific advances. Cytotoxic induction chemotherapy regimens are standard-of-care for most patients. Many investigations have highlighted the genomic heterogeneity of AML, and several ne...

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Détails bibliographiques
Publié dans:Front Oncol
Auteurs principaux: Tibes, Raoul, Bogenberger, James M.
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6920180/
https://ncbi.nlm.nih.gov/pubmed/31921615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.01205
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