Up-regulation of CDK9 kinase activity and Mcl-1 stability contributes to the acquired resistance to cyclin-dependent kinase inhibitors in leukemia

Flavopiridol is a small molecule inhibitor of cyclin-dependent kinases (CDK) known to impair global transcription via inactivation of positive transcription elongation factor b. It has been demonstrated to have significant activity predominantly in chronic lymphocytic leukemia and acute myeloid leuk...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Yeh, Yuh-Ying, Chen, Rong, Hessler, Joshua, Mahoney, Emilia, Lehman, Amy M., Heerema, Nyla A., Grever, Michael R., Plunkett, William, Byrd, John C., Johnson, Amy J.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4413609/
https://ncbi.nlm.nih.gov/pubmed/25596730
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