The Novel Cyclin-Dependent Kinase Inhibitor Dinaciclib (SCH727965) Promotes Apoptosis and Abrogates Microenvironmental Cytokine Protection in Chronic Lymphocytic Leukemia Cells

The cyclin dependent kinase (CDK) inhibitor flavopiridol has demonstrated promising clinical results in relapsed CLL patients leading to efforts to develop improved CDK inhibitors. Dinaciclib (SCH727965) is a pan-CDK inhibitor, derived from a detailed screen in ovarian xenograft mouse models for the...

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Detalhes bibliográficos
Main Authors: Johnson, Amy J., Yeh, Yuh-Ying, Smith, Lisa L., Wagner, Amy J., Hessler, Joshua, Gupta, Sneha, Flynn, Joseph, Jones, Jeffrey, Zhang, Xiaoli, Bannerji, Rajat, Grever, Michael R., Byrd, John C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3645353/
https://ncbi.nlm.nih.gov/pubmed/22791353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2012.144
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