Cyclin-dependent kinase inhibitor Dinaciclib (SCH727965) inhibits pancreatic cancer growth and progression in murine xenograft models

Pancreatic cancer is one of the most lethal of human malignancies, and potent therapeutic options are lacking. Inhibition of cell cycle progression through pharmacological blockade of cyclin-dependent kinases (CDK) has been suggested as a potential treatment option for human cancers with deregulated...

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Autori principali: Feldmann, Georg, Mishra, Anjali, Bisht, Savita, Karikari, Collins, Garrido-Laguna, Ignacio, Rasheed, Zeshaan, Ottenhof, Niki A, Dadon, Tikva, Alvarez, Hector, Fendrich, Volker, Rajeshkumar, NV, Matsui, William, Brossart, Peter, Hidalgo, Manuel, Bannerji, Rajat, Maitra, Anirban, Nelkin, Barry D
Natura: Artigo
Lingua:Inglês
Pubblicazione: Landes Bioscience 2011
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3218385/
https://ncbi.nlm.nih.gov/pubmed/21768779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.12.7.16475
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