Ectopic Overexpression of Sonic Hedgehog (Shh) Induces Stromal Expansion and Metaplasia in the Adult Murine Pancreas

Ligand-dependent activation of the Hedgehog (Hh) signaling pathway has been implicated in both tumor initiation and metastasis of pancreatic ductal adenocarcinoma (PDAC). Prior studies in genetically engineered mouse models (GEMMs) have assessed the role of Hh signaling by cell autonomous expression...

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Detalhes bibliográficos
Main Authors: Fendrich, Volker, Oh, Edwin, Bang, Seungmin, Karikari, Collins, Ottenhof, Niki, Bisht, Savita, Lauth, Matthias, Brossart, Peter, Katsanis, Nicholas, Maitra, Anirban, Feldmann, Georg
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press Inc. 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3201569/
https://ncbi.nlm.nih.gov/pubmed/22028618
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