Cyclin-dependent kinase inhibitor Dinaciclib (SCH727965) inhibits pancreatic cancer growth and progression in murine xenograft models

Pancreatic cancer is one of the most lethal of human malignancies, and potent therapeutic options are lacking. Inhibition of cell cycle progression through pharmacological blockade of cyclin-dependent kinases (CDK) has been suggested as a potential treatment option for human cancers with deregulated...

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Main Authors: Feldmann, Georg, Mishra, Anjali, Bisht, Savita, Karikari, Collins, Garrido-Laguna, Ignacio, Rasheed, Zeshaan, Ottenhof, Niki A, Dadon, Tikva, Alvarez, Hector, Fendrich, Volker, Rajeshkumar, NV, Matsui, William, Brossart, Peter, Hidalgo, Manuel, Bannerji, Rajat, Maitra, Anirban, Nelkin, Barry D
Format: Artigo
Jezik:Inglês
Izdano: Landes Bioscience 2011
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3218385/
https://ncbi.nlm.nih.gov/pubmed/21768779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.12.7.16475
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