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Autophagy and ER stress play an essential role in the mechanism of action and drug resistance of the cyclin-dependent kinase inhibitor flavopiridol

Chronic lymphocytic leukemia (CLL) is a mature B cell malignancy and is the most prevalent type of leukemia in adults. There is no curative therapy for this disease; however, several new agents have shown very promising results. Autophagy has not been studied in CLL and in this study we first sought...

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Detalhes bibliográficos
Main Authors: Mahoney, Emilia, Byrd, John C., Johnson, Amy J.
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3590270/
https://ncbi.nlm.nih.gov/pubmed/23422081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.23027
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