ER stress and autophagy: new discoveries in the mechanism of action and drug resistance of the cyclin-dependent kinase inhibitor flavopiridol

Cyclin dependent kinase (CDK) inhibitors, such as flavopiridol, demonstrate significant single-agent activity in chronic lymphocytic leukemia (CLL), but the mechanism of action in these nonproliferating cells is unclear. Here we demonstrate that CLL cells undergo autophagy after treatment with thera...

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Bibliografiset tiedot
Päätekijät: Mahoney, Emilia, Lucas, David M., Gupta, Sneha V., Wagner, Amy J., Herman, Sarah E. M., Smith, Lisa L., Yeh, Yuh-Ying, Andritsos, Leslie, Jones, Jeffrey A., Flynn, Joseph M., Blum, Kristie A., Zhang, Xiaoli, Lehman, Amy, Kong, Hui, Gurcan, Metin, Grever, Michael R., Johnson, Amy J., Byrd, John C.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society of Hematology 2012
Aiheet:
Lympoid Neoplasia
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3418721/
https://ncbi.nlm.nih.gov/pubmed/22740450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-12-400184
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