Efficacy of EGFR plus TNF inhibition in a preclinical model of temozolomide-resistant glioblastoma

BACKGROUND: Glioblastoma (GBM) is the most common primary malignant adult brain tumor. Temozolomide (TMZ) is the standard of care and is most effective in GBMs that lack the DNA repair protein O(6)-methylguanine-DNA methyltransferase (MGMT). Moreover, even initially responsive tumors develop a secon...

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Enregistré dans:
Détails bibliographiques
Publié dans:Neuro Oncol
Auteurs principaux: Guo, Gao, Gong, Ke, Puliyappadamba, Vineshkumar Thidil, Panchani, Nishah, Pan, Edward, Mukherjee, Bipasha, Damanwalla, Ziba, Bharia, Sabrina, Hatanpaa, Kimmo J, Gerber, David E, Mickey, Bruce E, Patel, Toral R, Sarkaria, Jann N, Zhao, Dawen, Burma, Sandeep, Habib, Amyn A
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2019
Sujets:
Basic and Translational Investigations
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6917414/
https://ncbi.nlm.nih.gov/pubmed/31363754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz127
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