Humanin induces conformational changes in the apoptosis regulator BAX and sequesters it into fibers, preventing mitochondrial outer-membrane permeabilization

The mitochondrial, or intrinsic, apoptosis pathway is regulated mainly by members of the B-cell lymphoma 2 (BCL-2) protein family. BCL-2–associated X apoptosis regulator (BAX) plays a pivotal role in the initiation of mitochondria-mediated apoptosis as one of the factors causing mitochondrial outer-...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Morris, Daniel L., Kastner, David W., Johnson, Sabrina, Strub, Marie-Paule, He, Yi, Bleck, Christopher K. E., Lee, Duck-Yeon, Tjandra, Nico
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6916494/
https://ncbi.nlm.nih.gov/pubmed/31690630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011297
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