Modified sites and functional consequences of 4-oxo-2-nonenal adducts in HDL that are elevated in familial hypercholesterolemia

The lipid aldehyde 4-oxo-2-nonenal (ONE) is a highly reactive protein crosslinker derived from peroxidation of n-6 polyunsaturated fatty acids and generated together with 4-hydroxynonenal (HNE). Lipid peroxidation product-mediated crosslinking of proteins in high-density lipoprotein (HDL) causes HDL...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: May-Zhang, Linda S., Yermalitsky, Valery, Melchior, John T., Morris, Jamie, Tallman, Keri A., Borja, Mark S., Pleasent, Tiffany, Amarnath, Venkataraman, Song, Wenliang, Yancey, Patricia G., Davidson, W. Sean, Linton, MacRae F., Davies, Sean S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2019
Soggetti:
Molecular Bases of Disease
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6916491/
https://ncbi.nlm.nih.gov/pubmed/31666337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009424
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