Modified sites and functional consequences of 4-oxo-2-nonenal adducts in HDL that are elevated in familial hypercholesterolemia

The lipid aldehyde 4-oxo-2-nonenal (ONE) is a highly reactive protein crosslinker derived from peroxidation of n-6 polyunsaturated fatty acids and generated together with 4-hydroxynonenal (HNE). Lipid peroxidation product-mediated crosslinking of proteins in high-density lipoprotein (HDL) causes HDL...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: May-Zhang, Linda S., Yermalitsky, Valery, Melchior, John T., Morris, Jamie, Tallman, Keri A., Borja, Mark S., Pleasent, Tiffany, Amarnath, Venkataraman, Song, Wenliang, Yancey, Patricia G., Davidson, W. Sean, Linton, MacRae F., Davies, Sean S.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Molecular Bases of Disease
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6916491/
https://ncbi.nlm.nih.gov/pubmed/31666337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009424
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