Modified sites and functional consequences of 4-oxo-2-nonenal adducts in HDL that are elevated in familial hypercholesterolemia

The lipid aldehyde 4-oxo-2-nonenal (ONE) is a highly reactive protein crosslinker derived from peroxidation of n-6 polyunsaturated fatty acids and generated together with 4-hydroxynonenal (HNE). Lipid peroxidation product-mediated crosslinking of proteins in high-density lipoprotein (HDL) causes HDL...

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Vydáno v:J Biol Chem
Hlavní autoři: May-Zhang, Linda S., Yermalitsky, Valery, Melchior, John T., Morris, Jamie, Tallman, Keri A., Borja, Mark S., Pleasent, Tiffany, Amarnath, Venkataraman, Song, Wenliang, Yancey, Patricia G., Davidson, W. Sean, Linton, MacRae F., Davies, Sean S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2019
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6916491/
https://ncbi.nlm.nih.gov/pubmed/31666337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009424
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