Modified sites and functional consequences of 4-oxo-2-nonenal adducts in HDL that are elevated in familial hypercholesterolemia

The lipid aldehyde 4-oxo-2-nonenal (ONE) is a highly reactive protein crosslinker derived from peroxidation of n-6 polyunsaturated fatty acids and generated together with 4-hydroxynonenal (HNE). Lipid peroxidation product-mediated crosslinking of proteins in high-density lipoprotein (HDL) causes HDL...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: May-Zhang, Linda S., Yermalitsky, Valery, Melchior, John T., Morris, Jamie, Tallman, Keri A., Borja, Mark S., Pleasent, Tiffany, Amarnath, Venkataraman, Song, Wenliang, Yancey, Patricia G., Davidson, W. Sean, Linton, MacRae F., Davies, Sean S.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2019
Matèries:
Molecular Bases of Disease
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6916491/
https://ncbi.nlm.nih.gov/pubmed/31666337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009424
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