Reactive Dicarbonyl Scavenging Effectively Reduces MPO-Mediated Oxidation of HDL and Restores PON1 Activity

Atheroprotective functions of high-density lipoproteins (HDL) are related to the activity of HDL-associated enzymes such as paraoxonase 1 (PON1). We examined the impact of inhibition of myeloperoxidase (MPO)-mediated HDL oxidation by PON1 on HDL malondialdehyde (MDA) content and HDL function. In the...

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Detalhes bibliográficos
Publicado no:Nutrients
Main Authors: Huang, Jiansheng, Yancey, Patricia G., Tao, Huan, Borja, Mark S., Smith, Loren E., Kon, Valentina, Davies, Sean S., Linton, MacRae F.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7400685/
https://ncbi.nlm.nih.gov/pubmed/32629758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/nu12071937
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