ATAD5 promotes replication restart by regulating RAD51 and PCNA in response to replication stress

Maintaining stability of replication forks is important for genomic integrity. However, it is not clear how replisome proteins contribute to fork stability under replication stress. Here, we report that ATAD5, a PCNA unloader, plays multiple functions at stalled forks including promoting its restart...

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Publicat a:Nat Commun
Autors principals: Park, Su Hyung, Kang, Nalae, Song, Eunho, Wie, Minwoo, Lee, Eun A., Hwang, Sunyoung, Lee, Deokjae, Ra, Jae Sun, Park, In Bae, Park, Jieun, Kang, Sukhyun, Park, Jun Hong, Hohng, Sungchul, Lee, Kyoo-young, Myung, Kyungjae
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6914801/
https://ncbi.nlm.nih.gov/pubmed/31844045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13667-4
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