ATAD5 restricts R-loop formation through PCNA unloading and RNA helicase maintenance at the replication fork

R-loops are formed when replicative forks collide with the transcriptional machinery and can cause genomic instability. However, it is unclear how R-loops are regulated at transcription-replication conflict (TRC) sites and how replisome proteins are regulated to prevent R-loop formation or mediate R...

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Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Kim, Sangin, Kang, Nalae, Park, Su Hyung, Wells, James, Hwang, Taejoo, Ryu, Eunjin, Kim, Byung-gyu, Hwang, Sunyoung, Kim, Seong-jung, Kang, Sukhyun, Lee, Semin, Stirling, Peter, Myung, Kyungjae, Lee, Kyoo-young
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2020
Sujets:
Genome Integrity, Repair and Replication
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7367208/
https://ncbi.nlm.nih.gov/pubmed/32542338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa501
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