Transcription factor dimerization activates the p300 acetyltransferase

The transcriptional coactivator p300 is a histone lysine acetyltransferase that is typically recruited to transcriptional enhancers and regulates gene expression by acetylating chromatin. Here we show that p300 activation directly depends on the activation and oligomerisation status of transcription...

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Udgivet i:Nature
Main Authors: Ortega, Esther, Rengachari, Srinivasan, Ibrahim, Ziad, Hoghoughi, Naghmeh, Gaucher, Jonathan, Holehouse, Alex S., Khochbin, Saadi, Panne, Daniel
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6914384/
https://ncbi.nlm.nih.gov/pubmed/30323286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0621-1
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