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Oncogenesis by sequestration of CBP/p300 in transcriptionally inactive hyperacetylated chromatin domains

In a subset of poorly differentiated and highly aggressive carcinoma, a chromosomal translocation, t(15;19)(q13;p13), results in an in-frame fusion of the double bromodomain protein, BRD4, with a testis-specific protein of unknown function, NUT (nuclear protein in testis). In this study, we show tha...

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Detalhes bibliográficos
Main Authors: Reynoird, Nicolas, Schwartz, Brian E, Delvecchio, Manuela, Sadoul, Karin, Meyers, David, Mukherjee, Chandrani, Caron, Cécile, Kimura, Hiroshi, Rousseaux, Sophie, Cole, Philip A, Panne, Daniel, French, Christopher A, Khochbin, Saadi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2944051/
https://ncbi.nlm.nih.gov/pubmed/20676058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.176
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