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Constitutive activation of MEK1 in osteoprogenitors increases strength of bone despite impairing mineralization
Recent clinical studies have revealed that a somatic mutation in MAP2K1, causing constitutive activation of MEK1 in osteogenic cells, occurs in melorheostotic bone disease in humans. We have generated a mouse model which expresses an activated form of MEK1 (MEK1DD) specifically in osteoprogenitors p...
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| Vydáno v: | Bone |
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| Hlavní autoři: | , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2019
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6914252/ https://ncbi.nlm.nih.gov/pubmed/31689526 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2019.115106 |
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