Canagliflozin, an SGLT2 inhibitor, corrects glycemic dysregulation in TallyHO model of T2D but only partially prevents bone deficits

Higher fracture risk in type 2 diabetes (T2D) is attributed to disease-specific deficits in micro-structural and material properties of bone, although the primary cause is not yet established. The TallyHO (TH) mouse is a polygenic model of early-onset T2D and obesity analogous to adolescent-onset T2...

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Publicado en:Bone
Main Authors: Thrailkill, Kathryn M., Bunn, R. Clay, Uppuganti, Sasidhar, Ray, Philip, Popescu, Iuliana, Kalaitzoglou, Evangelia, Fowlkes, John L., Nyman, Jeffry S.
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7852344/
https://ncbi.nlm.nih.gov/pubmed/32890778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2020.115625
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