Mycobacterium tuberculosis Requires Cholesterol Oxidase to Disrupt TLR2 Signalling in Human Macrophages

This study tested the hypothesis that Mycobacterium tuberculosis (Mtb) uses a cholesterol oxidase enzyme (ChoD) to suppress a toll-like receptor type 2- (TLR2-) dependent signalling pathway to modulate macrophages' immune response. We investigated the impact of Mtb possessing or lacking ChoD as...

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Detalhes bibliográficos
Publicado no:Mediators Inflamm
Main Authors: Szulc-Kielbik, Izabela, Kielbik, Michal, Przygodzka, Patrycja, Brzostek, Anna, Dziadek, Jaroslaw, Klink, Magdalena
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6913169/
https://ncbi.nlm.nih.gov/pubmed/31871425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/2373791
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