Inhibitable Photolabeling by Neurosteroid Diazirine Analog in the β3-Subunit of Human Hetereopentameric Type A GABA Receptors

Pregnanolone and allopregnanolone-type ligands exert general anesthetic, anticonvulsant and anxiolytic effects due to their positive modulatory interactions with the GABA(A) receptors in the brain. Binding sites for these neurosteroids have been recently identified at subunit interfaces in the trans...

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Publicado no:Eur J Med Chem
Main Authors: Wu, Bo, Jayakar, Selwyn S., Zhou, Xiaojuan, Titterton, Katherine, Chiara, David C., Szabo, Andrea L., Savechenkov, Pavel Y., Kent, Daniel E., Cohen, Jonathan B., Forman, Stuart A., Miller, Keith W., Bruzik, Karol S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6912599/
https://ncbi.nlm.nih.gov/pubmed/30544077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2018.11.019
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