Human iPSC-derived microglia assume a primary microglia-like state after transplantation into the neonatal mouse brain

Microglia are essential for maintenance of normal brain function, with dysregulation contributing to numerous neurological diseases. Protocols have been developed to derive microglia-like cells from human induced pluripotent stem cells (hiPSCs). However, primary microglia display major differences i...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Svoboda, Devon S., Barrasa, M. Inmaculada, Shu, Jian, Rietjens, Rosalie, Zhang, Shupei, Mitalipova, Maya, Berube, Peter, Fu, Dongdong, Shultz, Leonard D., Bell, George W., Jaenisch, Rudolf
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2019
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6911218/
https://ncbi.nlm.nih.gov/pubmed/31772018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1913541116
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