Human iPSC-derived microglia assume a primary microglia-like state after transplantation into the neonatal mouse brain

Microglia are essential for maintenance of normal brain function, with dysregulation contributing to numerous neurological diseases. Protocols have been developed to derive microglia-like cells from human induced pluripotent stem cells (hiPSCs). However, primary microglia display major differences i...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Svoboda, Devon S., Barrasa, M. Inmaculada, Shu, Jian, Rietjens, Rosalie, Zhang, Shupei, Mitalipova, Maya, Berube, Peter, Fu, Dongdong, Shultz, Leonard D., Bell, George W., Jaenisch, Rudolf
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6911218/
https://ncbi.nlm.nih.gov/pubmed/31772018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1913541116
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