Human iPSC-derived microglia assume a primary microglia-like state after transplantation into the neonatal mouse brain

Microglia are essential for maintenance of normal brain function, with dysregulation contributing to numerous neurological diseases. Protocols have been developed to derive microglia-like cells from human induced pluripotent stem cells (hiPSCs). However, primary microglia display major differences i...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Svoboda, Devon S., Barrasa, M. Inmaculada, Shu, Jian, Rietjens, Rosalie, Zhang, Shupei, Mitalipova, Maya, Berube, Peter, Fu, Dongdong, Shultz, Leonard D., Bell, George W., Jaenisch, Rudolf
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2019
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6911218/
https://ncbi.nlm.nih.gov/pubmed/31772018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1913541116
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