iPSC-derived human microglia-like cells to study neurological diseases

Microglia play critical roles in brain development, homeostasis, and neurological disorders. Here, we report that human microglial-like cells (iMGL) can be differentiated from iPSCs to study their function in neurological diseases, like Alzheimer’s disease (AD). We find that iMGLs develop in vitro s...

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Published in:Neuron
Main Authors: Abud, Edsel M., Ramirez, Ricardo N., Martinez, Eric S., Healy, Luke M., Nguyen, Cecilia H.H., Newman, Sean A., Yeromin, Andriy V., Scarfone, Vanessa M., Marsh, Samuel E., Fimbres, Cristhian, Caraway, Chad A., Fote, Gianna M., Madany, Abdullah M., Agrawal, Anshu, Kayed, Rakez, Gylys, Karen H., Cahalan, Michael D., Cummings, Brian J., Antel, Jack P., Mortazavi, Ali, Carson, Monica J., Poon, Wayne W., Blurton-Jones, Mathew
Format: Artigo
Language:Inglês
Published: 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5482419/
https://ncbi.nlm.nih.gov/pubmed/28426964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2017.03.042
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