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Cell-wide mapping of Orai1 channel activity reveals functional heterogeneity in STIM1-Orai1 puncta

Upon Ca(2+) store depletion, Orai1 channels cluster and open at endoplasmic reticulum–plasma membrane (ER–PM) junctions in signaling complexes called puncta. Little is known about whether and how Orai1 channel activity may vary between individual puncta. Previously, we developed and validated optica...

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Foilsithe in:J Gen Physiol
Main Authors: Dynes, Joseph L., Yeromin, Andriy V., Cahalan, Michael D.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Rockefeller University Press 2020
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7478869/
https://ncbi.nlm.nih.gov/pubmed/32589186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201812239
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