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Cell-wide mapping of Orai1 channel activity reveals functional heterogeneity in STIM1-Orai1 puncta

Upon Ca(2+) store depletion, Orai1 channels cluster and open at endoplasmic reticulum–plasma membrane (ER–PM) junctions in signaling complexes called puncta. Little is known about whether and how Orai1 channel activity may vary between individual puncta. Previously, we developed and validated optica...

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Bibliografiska uppgifter
I publikationen:J Gen Physiol
Huvudupphovsmän: Dynes, Joseph L., Yeromin, Andriy V., Cahalan, Michael D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Rockefeller University Press 2020
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7478869/
https://ncbi.nlm.nih.gov/pubmed/32589186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201812239
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