Fragment-based screening identifies molecules targeting the substrate-binding ankyrin repeat domains of tankyrase

The PARP enzyme and scaffolding protein tankyrase (TNKS, TNKS2) uses its ankyrin repeat clusters (ARCs) to bind a wide range of proteins and thereby controls diverse cellular functions. A number of these are implicated in cancer-relevant processes, including Wnt/β-catenin signalling, Hippo signallin...

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Vydáno v:Sci Rep
Hlavní autoři: Pollock, Katie, Liu, Manjuan, Zaleska, Mariola, Meniconi, Mirco, Pfuhl, Mark, Collins, Ian, Guettler, Sebastian
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6911004/
https://ncbi.nlm.nih.gov/pubmed/31836723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-55240-5
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