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Fragment-based screening identifies molecules targeting the substrate-binding ankyrin repeat domains of tankyrase
The PARP enzyme and scaffolding protein tankyrase (TNKS, TNKS2) uses its ankyrin repeat clusters (ARCs) to bind a wide range of proteins and thereby controls diverse cellular functions. A number of these are implicated in cancer-relevant processes, including Wnt/β-catenin signalling, Hippo signallin...
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| Udgivet i: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6911004/ https://ncbi.nlm.nih.gov/pubmed/31836723 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-55240-5 |
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