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Evidence for an effect of receptor density on ligand occupancy and agonist EC(50)
Drug-receptor interaction theory predicts that proportional receptor occupancy is a function of ligand concentration as defined by a ligand-receptor affinity constant, and is independent of receptor density. However, we previously observed that the EC(50) of 5-HT reduced as the density of 5-HT(3) re...
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| Gepubliceerd in: | Sci Rep |
|---|---|
| Hoofdauteurs: | , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Nature Publishing Group UK
2019
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6910986/ https://ncbi.nlm.nih.gov/pubmed/31836743 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-55361-x |
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