Micronuclei-based model system reveals functional consequences of chromothripsis in human cells

Cancer cells often harbor chromosomes in abnormal numbers and with aberrant structure. The consequences of these chromosomal aberrations are difficult to study in cancer, and therefore several model systems have been developed in recent years. We show that human cells with extra chromosome engineere...

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Détails bibliographiques
Publié dans:eLife
Auteurs principaux: Kneissig, Maja, Keuper, Kristina, de Pagter, Mirjam S, van Roosmalen, Markus J, Martin, Jana, Otto, Hannah, Passerini, Verena, Campos Sparr, Aline, Renkens, Ivo, Kropveld, Fenna, Vasudevan, Anand, Sheltzer, Jason M, Kloosterman, Wigard P, Storchova, Zuzana
Format: Artigo
Langue:Inglês
Publié: eLife Sciences Publications, Ltd 2019
Sujets:
Cell Biology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6910827/
https://ncbi.nlm.nih.gov/pubmed/31778112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.50292
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