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The presence of extra chromosomes leads to genomic instability
Aneuploidy is a hallmark of cancer and underlies genetic disorders characterized by severe developmental defects, yet the molecular mechanisms explaining its effects on cellular physiology remain elusive. Here we show, using a series of human cells with defined aneuploid karyotypes, that gain of a s...
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| Veröffentlicht in: | Nat Commun |
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| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4756715/ https://ncbi.nlm.nih.gov/pubmed/26876972 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10754 |
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