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Continuous chromosomal instability in human pluripotent stem cells – the role of DNA replication

Human pluripotent stem cells (hPSCs) frequently acquire chromosomal aberrations, including aneuploidy, during culture. Recently, we identified a replication stress-based mechanism leading to ongoing chromosomal instability in aneuploid hPSCs that may also operate during the initiation of instability...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Cell Oncol
Prif Awduron: Lamm, Noa, Kerem, Batsheva
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Taylor & Francis 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4972117/
https://ncbi.nlm.nih.gov/pubmed/27652327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2016.1183743
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